ABSTRACT
Neonatal seizure is one of the most common manifestations of newborns, which could lead to severe neurological sequelae, such as epilepsy, cerebral palsy, developmental delay, mental retardation and even death.The causes of neonatal seizures are the key factors contributing to prognosis.In addition, individual factors, types of seizure and EEG could affect the prognosis in varying degrees.Therefore, for patients with poor prognosis, early diagnosis and treatment could effectively improve the prognosis and reduce the mortality.
ABSTRACT
Objective@#To explore the relationship between features of neonatal seizure and recent outcomes of patients with unexplained neonatal seizure, which may provide evidence for early assessment of prognosis.@*Methods@#Forty-seven cases of unexplained neonatal seizure admitted to the Department of Neonatology in Shengjing Hospital of China Medical University from January 2014 to June 2018, were followed-up at the age of more than 6 months.According to the recent outcomes(recurrent seizures during non-neonatal period and levels of development when they were followed-up), the patients were divided into good recent outcomes group(34 cases)and poor recent outcomes group(13 cases). The general information, characteristics of seizure and EEG changes during neonatal period were analyzed retrospectively.@*Results@#There was no significant difference in gender, gestational age, birth weight, onset of first seizure, type of seizure, duration of seizure, and interval of seizures between two groups(P>0.05). There were 11 cases in poor recent outcomes group and 30 cases in good recent outcomes group that finished EEG.Compared with patients with good recent outcomes, patients with poor recent outcomes had significantly more abnormal EEG, paroxysmal abnormal changes and paroxysmal abnormal changes with abnormal background activity(90.9% vs.43.3%, 63.6% vs.10.0%, 36.4% vs.6.7%), with statistically significant difference(P<0.05). Thirty-nine cases with recurrent seizures during non-neonatal period had significantly higher rate of dysplasia than the 34 cases that without recurrent seizures(50.0% vs.12.8%), with statistically significant difference(P<0.05).@*Conclusion@#The recent outcomes of unexplained neonatal seizure may be related the EEG changes, but not gender, gestational age, birth weight, features of seizure.The neonates with unexplained neonatal seizure whose EEG manifest as paroxysmal abnormalities, were more likely to get poor recent outcomes, such as recurrent seizures and(or)dysplasia during non-neonatal period.
ABSTRACT
Objective To explore the relationship between features of neonatal seizure and recent outcomes of patients with unexplained neonatal seizure,which may provide evidence for early assessment of prognosis.Methods Forty-seven cases of unexplained neonatal seizure admitted to the Department of Neonatology in Shengjing Hospital of China Medical University from January 2014 to June 2018,were followed-up at the age of more than 6 months.According to the recent outcomes (recurrent seizures during non-neonatal period and levels of development when they were followed-up),the patients were divided into good recent outcomes group (34 cases) and poor recent outcomes group (13 cases).The general information,characteristics of seizure and EEG changes during neonatal period were analyzed retrospectively.Results There was no significant difference in gender,gestational age,birth weight,onset of first seizure,type of seizure,duration of seizure,and interval of seizures between two groups (P ＞ 0.05).There were 11 cases in poor recent outcomes group and 30 cases in good recent outcomes group that finished EEG.Compared with patients with good recent outcomes,patients with poor recent outcomes had significantly more abnormal EEG,paroxysmal abnormal changes and paroxysmal abnormal changes with abnormal background activity (90.9％ vs.43.3％,63.6％ vs.10.0％,36.4％ vs.6.7％),with statistically significant difference (P ＜ 0.05).Thirty-nine cases with recurrent seizures during non-neonatal period had significantly higher rate of dysplasia than the 34 cases that without recurrent seizures (50.0％ vs.12.8％),with statistically significant difference (P ＜0.05).Conclusion The recent outcomes of unexplained neonatal seizure may be related the EEG changes,but not gender,gestational age,birth weight,features of seizure.The neonates with unexplained neonatal seizure whose EEG manifest as paroxysmal abnormalities,were more likely to get poor recent outcomes,such as recurrent seizures and (or) dysplasia during non-neonatal period.
ABSTRACT
Amplitude-integrated electroencephalogram(aEEG)is a new method for bedside monitoring of cerebral function which is gradually used in clinical routine.Although the grading criteria has not been unified, some studies suggest that aEEG recorded during the very early period after birth can not only indicate the maturation of brain development, but also provide values of clinical application on the early identification, determination of the severity and long-term prognosis assessment of brain injury(e.g.white matter injury, intracranial hemorrhage, etc.)in premature infants.